“Quantitative Proteomics of rhGH-Doping by Multiplexed Stable Isotope Labeling and MALDI-TOF/TOF Mass Spectrometry”
نویسندگان
چکیده
The detection of doping with recombinant peptide and protein hormones (e.g. human growth hormone -hGH, erythropoietin Epo) is one of the most challenging analytical problems in doping control. Rapid metabolic degradation paired with a low medical dosing strategy reduces the time window for a successful direct detection by immunological methods in the case of hGH to just a few hours after the last application.
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